Spurs proved last season they could manage the riding of two horses in both the Europa League and Premier League while nearly going the distance, so yes. The Champions League might even seem more manageable because they’ll enjoy the slightest sliver of extra time when playing in the Tuesday or Wednesday/ Saturday schedule rather than the Europa League Thursday/Sunday set-up.
Spurs now have the right manager in place in Mauricio Pochettino, and while neither he nor his players have much Champions League experience between them, the best way to get it is to actually play the games. Their group includes Monaco, Spartak Moscow and Bayer Leverkusen so all four teams will fancy their chances of progressing. As long as Spurs play with the same energy as they do in the league, I can’t see why they won’t get out of the group.
Some people have pointed to the fact that playing at Wembley, rather than hotbed at White Hart Lane might be disadvantageous. And yes, Spurs might lose that impenetrable feel that the stadium had during their last Champions League campaign where they beat Inter Milan. But on the other hand, everybody wants to play at Wembley. You can’t have it both ways.